Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in D-galactose-induced aging rats
نویسندگان
چکیده
منابع مشابه
Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in d-galactose-induced aging rats
BACKGROUND Recently, the d-galactose (d-gal)-induced mimetic aging rat model has been widely used in studies of age-associated diseases, which have shown that chronic d-gal exposure induces premature aging similar to natural aging in rats. With the increasing rate of sepsis in the geriatric population, an easy-access animal model for preclinical studies of elderly sepsis is urgently needed. Thi...
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Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...
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ژورنال
عنوان ژورنال: Clinical Interventions in Aging
سال: 2017
ISSN: 1178-1998
DOI: 10.2147/cia.s132277